New trial to explore genetic test for cancer risk in GP setting

Researchers from the University of Melbourne have received $2.4 million from the Medical Research Future Fund (MRFF) to explore whether a new DNA test collected via a simple saliva swab at the doctor’s office could be a cost-effective and efficient way to evaluate genetic vulnerability to certain cancers.

The CASOWARY (CAncer genomic riSk ScOres in primARY Care) trial is a multi-site study led by Professor Jon Emery  from the Cancer in Primary Care group, using genomics-based tests developed by Genetic Technologies Limited.

The study will recruit nearly 600 participants from eight general practice sites across Victoria, generating high-quality evidence assessing the viability of using DNA testing to screen for risk of four of the most common cancers in Australia: breast, colorectal, prostate, and melanoma.

Professor Jon Emery, said DNA testing can aid in the prevention and early detection of cancer by allowing doctors to offer personalised risk management strategies.

“This is the first trial in Australia to study the impact of providing this type of genomic information to patients in general practice, including recommended screening tests according to their cancer risks,” Professor Emery said.

“At present, cancer screening programs like BreastScreen and the National Bowel Cancer Screening Program treat everyone as if they have the same risk of cancer. Future screening programs will be adapted to account for an individual's risk of different cancers.

"This might mean starting some screening at a younger age or using more intensive tests. For those at lower risk, they might be told they don't need to start screening until they are older, or do not really need it at all.

“The trial will tell us if this risk-based approach, using a single DNA test to begin with, is more effective and efficient, and whether we really can target screening to those most likely to benefit.”

The Medical Research Future Fund (MRFF) is an ongoing research fund set up by the Australian Government in 2015. Read more about the MRFF via the website.